Monastiraki lies in the valley of Amari, on the natural route leading from northern Crete to the Messara plain. Excavations have brought to light a centre of the Old Palace period (1950-1700 B.C.). which was destroyed by fire following an earthquake. The large number of storerooms and the existence of two archive rooms with many clay sealings indicate a palatial character for the site. Other finds on the top of a neighbouring hill suggest there must have been a religious centre in the area, as well.

The exhibition of the objects takes place according to the contemporary museum conception, with explanatory texts, photographs, plans, models, and is enriched with new exhibits every year. The Museum is divided into seven rooms, according to the following units: The Arched House, Silk, Pottery, Lace-making, Masonry and Stone carving, Church and Woodcarving.